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The diabetes and weight loss drug Tirzepatide sold as Mounjaro and Zepbound, respectively significantly improved heart failure symptoms and related physical limitations in a Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has shown promise in the treatment of type 2 diabetes and obesity

Additionally, the risk of bias was considered low or unclear across the studies for the remaining elements of bias assessment

Nausea affects a substantial percentage of users, particularly during dose escalation

Liraglutide: Liraglutide (brand name Saxenda) is another GLP-1 receptor agonist, similar to Semaglutide

Works well for many patients, especially those new to GLP-1 therapy