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Other neurochemicals, including serotonin, neurokinin B, and calcitonin gene-related peptide (CGRP), are believed to influence the sensitivity of the thermoregulatory center and may contribute to both the frequency and severity of hot flashes

Unlike many drugs, it is not metabolized by liver enzymes (such as CYP enzymes), which can reduce the risk of drug interactions

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PubMed Xiao, B., Xu, Z., Viennois, E., Zhang, Y., Zhang, Z., Zhang, M., Han, M.K., Kang, Y., Merlin, D

Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis