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Nasal mucosa allows direct absorption into systemic circulation, though some compound inevitably drains into the throat and undergoes first-pass metabolism

97 In addition to single-nucleotide polymorphisms, de novo copy number variations have been implicated in autism at six chromosomal locations, as shown in Table 1, implicating 65 risk genes in several pathways including, but not limited to, chromatin remodeling involving lysine methylation/demethylation, zinc fingers, transcription factors, and synaptic proteins

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doi:10.1073/pnas.2436556100 Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y