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Due to study heterogeneity, random-effects models were applied

Antioxidants 9 , 595 (2020)

According to NICE guidelines, these medications should be prescribed only as part of a specialist weight management service (Tier 3 or 4), not as standalone treatment

indicates that PAC, in the absence of adequate, physiological levels of GSH, may give rise to genotoxic quinone imine metabolites ( The production of quinone imine metabolite is the primary responsible for PAC liver and kidney toxicity