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Acute and short-to-medium-term exposures were mainly studied by cell/ in vitro and animal studies 18,22,25-29,31,33-37,39-52 , while a single longitudinal study 20 examined long-term exposure

population is 78.8 years

Many e cigarette users are former cigarette smokers, and research suggests the effects of vaping are less severe than those experienced by people who smoked traditional cigarettes

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In the next step, we analyzed glycolysis, which usually compensates for reduced mitochondrial ATP production by OXPHOS (Fig