Blame stress, bad lighting, or maybe my zero-effort skincare
Proper storage is also essential
Liraglutide was developed with a view to providing a human GLP-1 analogue with a suitable duration of action for daily use, but, inspired by its beneficial actions, the company now strived to develop a second generation version, optimised not only with respect to duration of action, but also with respect to effects on insulin secretion and food intake
Most of the foundational studies are animal models, with a growing body of clinical observation and anecdotal reporting from practitioners and patients
While these effects initially made GLP-1 seem a promising candidate for drug development, the earliest clinical studies from 1992 and 1993 revealed that GLP-1s half-life in the body was disappointingly short