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They are especially promising given their long duration of action, decreased risk of hypoglycemia, and added benefit of weight loss

In some cases, it may lead to thyroid dysfunction, which can impact hormonal regulation in the body

Nutrients, 14(8), 1549

The tirzepatide adjustment timeline and the general GLP-1 onset period both illustrate that temporary discomfort often precedes significant benefit

According to FDA labeling for Wegovy (semaglutide), patients should be evaluated after 12 weeks at the maintenance dose (2.4 mg weekly), with discontinuation considered if less than 5% body weight reduction has been achieved