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Nonetheless, associations were widespread, including most of the cortex and sparing only some primary motor/sensory and occipital areas." "Comparing ex-smokers with current smokers revealed a similar but less extensive pattern of thinner cortex for current smokers." "A highly significant association between smoking status and mean cortical thickness was observed." "Rate of thinning in current smokers, revealed, within areas of pack-years-associated cortical thinning, that mean cortical thickness was 3.21 m thinner for every pack-year smoked." "This suggests that it takes ~0.9 years without smoking, to recover from the possible cortical thinning effect of each pack-year." "On this basis and given that the average pack-years in this sample's current and ex-smokers was 29.7, it took roughly 25 years without smoking for differences in cortical thickness to no longer be observed between ex-smokers and those that never smoked." "This study demonstrates a dose-dependent negative association between cigarette smoking and cortical thickness that is more extensive than previously reported." "Findings here suggest that cortical recovery could take as little as a few weeks to more than a theoretical 140 years (mean of ~25 years for t he LBC1936), depending on the amount smoked over one's lifetime." Study Citation: Karama S, Ducharme S, Corley J, Chouinard-Decorte F, Starr JM, Wardlaw JM, Bastin ME, Deary IJ

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