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Pentose Phosphate Pathway: Oxidative Phase The overall reaction of the oxidative phase of the pentose phosphate pathway is shown below: Glucose 6-phosphate + 2 NADP+ + H2O Ribulose 5-phosphate + 2 NADPH + 2 H+ + CO2 In the first step of the oxidative phase, glucose 6-phosphate is oxidized to 6-phosphoglucono--lactone, which is a lactone or cyclic ester (Figure 1)

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