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This is because B12 acts on the bone marrow to normalize red blood cell creation, and the life cycle of a red blood cell is 90 days

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Rubin RT, Phillips JJ, Sadow TF, McCracken JT

The exact magnitude varies widely, from modest improvements to dramatic transformations depending on starting point and adherence

Indeed, because more than 100 proteins have been reported as TG2 substrates and because TG2 has broad substrate specificity, the GST tag could be crosslinked with a number of cellular proteins 21