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doi: 10.1038/tpj.2012.43 22 HeJ.LiY.CaoY.XueJ.ZhouX

Differentially Abundant Genera in Healthy and OSCC Oral Microbiome and Their Comparison With Taxonomic Composition of Tobacco Products As per the observations from beta diversity analysis, four major groups of samples (healthy smokeless-tobacco-non-consuming, healthy smokeless-tobacco-consuming, OSCC tumor site and OSCC contralateral buccal site) were considered for further analysis

Acetylcholine : The presence of this small molecule stimulates pain nerves

[101] Cannabis smoking was introduced to Sub-Saharan Africa through Ethiopia and the east African coast by either Indian or Arab traders in the 13th century or earlier and spread on the same trade routes as those that carried coffee, which originated in the highlands of Ethiopia

Still, the review adds weight to a growing argument in tobacco science