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This leads to an increase in protein synthesis in muscle cells, promoting muscle hypertrophy and optimal muscle growth

A meta-analysis of GLP-1RA CVOT showed that treatment with GLP-1RA reduced the risk of developing a composite kidney outcome including new-onset MA by 21% compared to placebo (HR 0.79, 95% CI 0.73-0.87), with only ELIXA and EXSCEL not achieving significant benefit [11]

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Changes in the abundance of certain microbiota were also not identical across studies, and it is even possible to draw opposite conclusions

Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans