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Support for Tissue Repair Laboratory studies have reported effects on fibroblast activity, wound closure, and tendon-related repair mechanisms

Since histidine (His) in position 2 and tryptophan (Trp) in position 3 appeared to have receptor binding and functional effects 16

In addition to biopsy and histologic study, various laboratory and clinical tests, including diascopy, radiography, and blood tests, may be necessary for the definitive diagnosis of oral pigmentations

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