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Martin H et al (2022) Insulin modulates emotional behavior through a serotonin-dependent mechanism

If you keep it on longer, theres no risk or benefit because the patch is no longer effective after 12 hours

Toxicol Appl Pharmacol 263(3):315322 Chiarini A, Gui L, Viviani C, Armato U, Dal Pr I (2023) NLRP3 Inflammasome's activation in acute and chronic brain diseasesan update on pathogenetic mechanisms and therapeutic perspectives with respect to other inflammasomes

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For example, peptide YY and glucagon-like peptide-1 (GLP-1) are released in response to food intake and influence appetite and glucose metabolism, with receptors in the brain that affect satiety and cognitive function [43]