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Fe 3+ can bind to transferrin (TF) in serum and is subsequently taken up by the TF receptor 1 (TfR1), which is encoded by TFRC on the cell membrane [8].Fe 3+ taken up into the cell is reduced to Fe 2+ by STEAP3 metalloreductase in the endosome, and then is stored in ferritin and ultimately released again by ferritin phagocytosis-mediated ferritin degradation [9, 10]

PMID 21480318