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362 Considering the expression of the GLP-1R in thyroid C cells and the ability of GLP-1 to stimulate calcitonin secretion through a cAMP-mediated mechanism in vitro, it is plausible that calcitonin plays a role in the alterations in bone metabolism observed in GLP-1R-treated animals
Four studies interestingly showed a protective effect
Adverse effects These drugs are not being regulated as tightly, which could lead to inconsistent dosages , unverified ingredients, or contaminants, increasing the risk of severe nausea, vomiting, diarrhea, blood sugar fluctuations, allergic reactions, and infections
For weight management (NICE TA875 for semaglutide 2.4mg/Wegovy and TA664 for liraglutide 3mg/Saxenda): Treatment should be discontinued if specific weight loss targets are not met (typically at least 5% of initial body weight at 12-16 weeks)
Semaglutide slows gastric emptying, which could theoretically reduce levothyroxine absorption if taken together, so space them apart by at least one hour if possible
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