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[8] [9] At age seven, DeChambeau moved to Clovis, California

Nicotine, the main active ingredient in tobacco, is highly addictive

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So I come in and I was just really jittery

This activation triggers intracellular signaling cascades including the extracellular signal-regulated kinase (ERK) pathway, which increases expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF)