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In addition to GLS inhibitors, strategies that target the conversion of glutamate to -ketoglutarate, such as GDH inhibitors and transaminase inhibitors, have also been evaluated in preclinical models of breast cancer and neuroblastoma..

To view a copy of this licence, visit About this article Cite this article Batiha, G.ES., Al-kuraishy, H.M., Al-Gareeb, A.I

Consequently, NRF2 SUMOylation plays a key role in promoting signaling pathways that support HCC tumorigenesis, both under normal conditions and in response to metabolic stress [131]

Sci Rep 10 , 18341 (2020)

189 Until now there has been limited knowledge about the antioxidant status in AATD individuals, so the usefulness of antioxidant therapies remains to be investigated