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GLP-1 receptor agonists are hydrophilic proteins with molecular weights exceeding 3,000 Daltonsfar above the typical 500 Da threshold for effective passive skin penetration

Research indicates that breastfeeding women require 300500 more calories daily

As with many of the options on this list, it is not FDA-approved for use as a weight loss medication

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A population PK analysis in patients with major depressive disorder showed no substantial change in plasma concentrations of fluoxetine (20 mg/day or 40 mg/day), paroxetine CR (37.5 mg/day or 50 mg/day), or sertraline (100 mg/day or 150 mg/day) dosed to steady-state