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*Correspondence: Wen Luo, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The multiple therapeutic paradigms of VPA may be attributable to various mechanisms of action (MoAs), especially epigenetic effects

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pyroglutamic (5-oxoproline) acidosis pyroglutamic (5-oxoproline) acidosis pathophysiology pathogenesis of pyroglutamic acidosis The primary driver may be cysteine deficiency : Cysteine deficiency causes glutamylcysteine to be shunted into 5-oxoproline

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