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1 Introduction Inflammatory respiratory diseases represent formidable public health challenges, substantially diminishing patient quality of life while imposing considerable healthcare and economic burdens ( Current therapeutic approaches emphasize symptom management through bronchodilators, antibiotics, and inhaled corticosteroids, yet these interventions fail to fundamentally alter disease progression ( Recently, dipeptidyl peptidase 1 (DPP1) has emerged as a promising therapeutic target, functioning as the critical regulatory enzyme for NSP activation ( 2 Biological functions of DPP1 and NSPs 2.1 Structural and functional characteristics of DPP1 DPP1 functions as a lysosomal cysteine protease with an approximate molecular weight of 200 kDa, characterized by a distinctive tetrameric architecture

doi: 10.5812/jssc.65815

Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides

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