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Enclosed by the rib cage, they are protected and separated by the mediastinum

READ MORE: 13 ways smoking affects the body While the statistics are alarming, the good news is that quitting smoking reduces the risk of disease and death significantly

Key Takeaways Nicotine can reduce appetite and increase short-term energy expenditure in controlled studies, but effects are modest and can fade with tolerance, according to a review on nicotines effects on energy balance

The inferred increased risk of malignant transformation is well documented however controversy still persists in terms of the appropriate management for these lesions

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