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Postoperative changes In patients with obesity, elevated circulating leptin levels can result in excessive stimulation of leptin receptors, leading to receptor desensitization and impaired signaling, contributing to the dysregulation of energy balance seen in obesity

Abd Eldaim MA, Ibrahim FM, Orabi SH, Hassan A, El Sabagh HS (2018) l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF- and TGF-1

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Off-Label Use: A Growing Concern GLP-1s approved for T2D are frequently used off-label for weight loss, raising concerns among both employers and health plans