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In April 2025, Blue Cross Blue Shield of Massachusetts (BCBSMA), the states largest insurer, announced that it would end coverage of GLP-1 medications for obesity treatment beginning in January 2026, a move that will significantly restrict access for Boston residents who depend on these treatments

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Using wearable heart rate and HRV data, we found that GLP-1 treatment shifts the relationship between exercise load and recovery with implications for how active individuals should think about training while on medication

Resmetirom (MGL-3196) addresses this issue by selectively activating THR- with a 28-fold affinity compared to THR- [16]

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