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Then researchers proposed that heterozygous knockout mice appeared to be a good animal model for individuals homozygous for the C667T polymorphism, whereas the homozygous null mice were a better one for severely MTHFR-deficient individuals 19

We propose that SNX2a modulates SNX1 activity by altering the conformation or membrane interaction dynamics of the heterodimer, thereby fine-tuning membrane curvature generation

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The protein is particularly studied for its interactions with activin proteins, which are signalling molecules involved in cellular growth regulation, tissue development and various intracellular regulatory pathways