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The rationale is dual-pathway activation: CJC-1295 (GHRH analog) activates the GHRH receptor to stimulate GH synthesis and baseline release Ipamorelin (ghrelin mimetic) activates GHS-R1a to amplify GH pulse amplitude By engaging both regulatory pathways simultaneously, researchers have observed synergistic GH elevation greater than either compound alone

This study reports that activated platelets release mitochondria, either free or embedded in extracellular vesicles, that activate the immune system and participate in immune dysregulation in SLE