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Diabetes lowers exposure by about 15% and blunts the downstream response. Lean, metabolically healthy users sit outside every efficacy trial

Phase 3 trial of CagriSema in obesity without T2DM

Genetic Factors and Individual Variability in Semaglutide Response During Training Genetic variants in GLP-1 receptor signaling (GLP1R rs6923761), appetite regulation (MC4R rs17782313), and metabolic processing influence how aggressively semaglutide suppresses appetite and affects energy utilization

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