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Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding

In vitro and in vivo experiments confirm that exosomal modulation of this axis elevates GPX4 expression and mitigates joint inflammation and degeneration (189)

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(PubMed) Powers HJ, Weaver LT, Austin S, Beresford JK