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Unlike many therapeutic peptides, Dihexa can cross the blood-brain barrier and promote BDNF signaling , a key process for: These effects have made Dihexa of great interest in treating neurological diseases, age-related cognitive decline, and more recently, brain fog and fatigue

When B12 is given this way, it goes directly into the bloodstream through the muscle tissue instead of first passing through the digestive system

PLOS ONE, 15(9), e0239252

Initial signs of response typically appear by week 3-4, with meaningful results developing through weeks 5-8

It also raises blood pressure, increasing the risk of stroke