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These findings indicate that metformin could help sustain weight loss achieved with GLP-1 RAs, supporting their role in long-term weight maintenance across the treatment continuum

Nonetheless, this cooperative effect is subject to variations related to caffeine tolerance, coffee intake levels, as well as individual health condition parameters

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So far, the available evidence suggests that the muscle mass lost during weight loss with incretin RAs is comparable to other interventions inducing weight loss, such as diet and bariatric surgery, and that it is an adaptive process, comparable to the reduction in LV mass upon arterial blood pressure lowering (84)

Caffeine blocks adenosine receptors in the brain, which is what makes us feel alert