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Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM

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10.1016/j.jep.2021.113870 687

Based on these observations it was concluded that folding of permuted dihydrofolate reductase variants was terminated at the stage of the molten globule formation, whereas their interaction with ligands promoted structural adjustments and formation of active protein molecules, indicating ligand-induced transition from the molten globule to the native state (Uversky et al., 1996)

Posthoc, we noted that the incremental increase in integrated insulin and C-peptide concentrations during the first 30 minutes of hyperglycemia was decreased by exendin 9-39 infusion in people without diabetes