1 Introduction Heated Tobacco Products (HTPs), which are increasingly popular as alternatives to conventional cigarettes, has been actively promoted by industry manufacturers ( Research related to HTP usage has mainly focused on nicotine emissions, exposure biomarkers, and pharmacokinetics ( max ) and lower nicotine delivery, potentially increasing their addictive potential ( HTP aerosol is generated through medium-temperature ( 0.05), suggesting comparable levels of reinforcement
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