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Glucagon-like peptide-1 receptor pathway attenuates platelet activation in aspirin-exacerbated respiratory disease

Although glucagon-like peptide-1 receptor (GLP-1R) agonists have been used as anti-diabetic drugs and GLP-1R has been detected in the heart, the cardioprotective effects of GLP-1R agonists on the inhibition of MG-induced oxidative stress and mitochondrial abnormalities have not been elucidated

Informed by the structural data of Pt GSTF8, the accompanying mutagenesis experiments and the QM/MM studies, we investigated the impact of a disulfide bond between C13 and GSH on dehydratase activity

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