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Herein, we present a cross-sectional study on a cohort of 75 cEDS patients from 44 families with a confirmed molecular diagnosis focusing on the diagnostic criteria recognized in the current EDS nosology and on additional mucocutaneous, osteoarticular, musculoskeletal, cardiovascular, gastrointestinal, uro-gynecological, neuropsychiatric, atopic, and facial/ocular features, in order to investigate the multisystemic involvement and natural history of the disorder

(0:38) 1947 radio advertisement for Chesterfield cigarettes (0:44) 1947 radio advertisement for Camel cigarettes features the campaign slogan, Experience is the best teacher. (1:12) Audio clip of radio program, This is Your Life (1948-1952), sponsored by Philip Morris cigarettes (2:01) Audio clip of a 1950 radio spot for Philip Morris cigarettes (3:35) 1954 radio advertisement for Winston cigarettes features the jingle, Winston tastes good like a cigarette should. (0:41) 1965 radio advertisement for Salem cigarettes (1:02) Television Commercials By the 1950s, TVs were in every home, and tobacco companies were major sponsors of popular programs on every national network

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