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Hypochlorhydria may, in fact, be more common in the aging population as the gut physiology changes [64], and the use of certain medications can also impact hydrochloric acid levels [65]

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Modulating the gut microbiome and restoring gut barrier integrity are key therapeutic avenues, and several microbiome-targeted strategies have been explored [19,78,79]

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McCay CM, Crowell MF, Maynard LA