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References: The Real Truth Behind Weight-Loss Medications Good Shepherd Health Webinar from 11/2/2023 HaloScrips (Phil Baker and Michell Zulu, PharmDs) Ben Bohonowicz (EBS of MD)

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Hyperglycemia increases the production of Amyloid Beta-peptide leading to decreased endothelial tight junction

These include: Blood glucose readings above your target range, especially if over 300 mg/dL Increased thirst and urination Unexplained fatigue or weakness Fruity-smelling breath Nausea or vomiting (which may indicate hyperglycemia rather than medication side effects) Seek urgent care if your blood glucose is above 300 mg/dL or above 250 mg/dL with moderate to large ketones, if you have persistent vomiting, inability to keep fluids down, confusion, or signs of dehydration

Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice