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TABLE 1 Antituberculous medications known to be CYP450 enzyme system substrates or can impact its metabolic activity, possible effects of tobacco smoke compounds, and resulting potential interactions

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[45] There are two primary hypotheses: one proposes that syphilis was carried to Europe from the Americas by the crew of Christopher Columbus in the early 1490s, while the other proposes that syphilis previously existed in Europe but went unrecognized