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Although many studies have failed to measure NRF2 expression after sleep deprivation, most available data from systematically reviewed animal studies suggest an increased expression of key antioxidant enzymes regulated by NRF2, such as GSH, GPx, CAT, and SOD (Villafuerte et al

The specificity of ubiquitination is conferred by Ub E3 ligase complexes, which serves as the substrate receptor and recruits E2 enzymes that catalyze transfer of Ub to a substrate lysine

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Clinical trials show that gastrointestinal side effects plateau at therapeutic doses in most patients

A.SundaramoorthyV.SultanaJ