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Kim YH, Noh JR, Hwang JH, Kim KS, Choi DH, Kim JH, Moon SJ, Choi JH, Herault Y, Lee TG, Choi HS, Lee CH
10.3892/ijmm.2023.5288 Int
Key pharmacological characteristics include: Short half-life: Approximately 10-20 minutes Pulsatile stimulation: Mimics the bodys natural GH release pattern Self-limiting mechanism: The pituitarys negative feedback system prevents excessive GH production Peak activity during sleep: When administered before bed, sermorelin enhances the natural nocturnal GH surge A clinical study published in the Journal of Clinical Endocrinology & Metabolism demonstrated that sermorelin administration increased GH secretion and IGF-1 levels in older adults with documented age-related GH decline, with improvements in body composition and sleep quality (Vittone et al., 1997, JCEM )
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