(2018) found that there may be limited CNS penetration in oral administration compared to IV, as shown by increases in GSH/GSSG and catalase but not cerebral GSH levels
Science 193, 673675
References Richie JP Jr, et al
[DOI] [PubMed] [Google Scholar] [91].Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K, Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients
This inhibition was attributed to the reduction in IL-8) production from macrophages and pulmonary epithelial cells [19]