People in one study lost an average of about 6% of their body weight over six months while taking metformin
When introduced systemically, it travels through your bloodstream, instructing your fibroblasts (the cells that make collagen) to get back to work
This pattern aligns with our previous work in DIO male mice using the same semaglutide dose, where we observed an approximately 20% reduction in EDL force after one week of the treatment that recovered by week three, despite no changes in fiber CSA or fiber-type composition (14)
Quick answer: Yes, you can gain weight on semaglutide, and regain after stopping is common because the drugs appetite-suppressing effects wear off
Researchers still weighing the combination rationale itself, rather than the dosing arithmetic, should review the CJC-1295 vs Ipamorelin: individual peptide comparison before finalising a protocol