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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints ( In most cases, joint pain is due to damage to the articular cartilage

Measurement of FAO activity FAO activity in HK-2 cells was measured using FAO blue reagent (FDV-0033, Funakoshi Co, Ltd., Tokyo, Japan) (11)

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