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Pleiotropic modulation of thymic function by growth hormone: from physiology to therapy

Goren A, Wambier CG, Herrera S, McCoy J, Vao-Galvn S, Gioia F, Comeche B, Ron R, Serrano-Villar S, Ramos PM, Cadegiani FA, Kovacevic M, Tosti A, Shapiro J, Sinclair R

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In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

The IVD is a fibrocartilaginous tissue that sits between and connects two adjacent vertebral bodies and is composed of the external AF, the inner gel-like center NP, and the cartilaginous endplates that serve as a connection to the vertebrae