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When you inhale, air travels down your windpipe (trachea), through branching tubes called bronchi, and into even smaller bronchioles, much like an upside-down tree

you get symptoms of nicotine overdose such as nausea, vomiting, dizziness, weakness and rapid heartbeat

In addition, e-cigarette use has been linked to lung diseases, including pneumonia, respiratory bronchiolitis-associated interstitial lung disease (an inflammatory disease previously seen mainly in heavy tobacco smokers), and hypersensitivity pneumonitis (a type of allergic reaction in the lungs), according to a 2022 review published in the journal Annual Review of Physiology

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This can create a mutual effect in the brain when nicotine and alcohol are consumed together, reinforcing each others addictive properties