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Par ailleurs, les deux molcules interviennent dans des compartiments cellulaires complmentaires : toutes deux hydrosolubles, elles agissent dans le cytoplasme et les milieux extracellulaires, en synergie avec dautres acteurs du systme antioxydant endogne

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These findings establish ATM modulation as a strategic therapeutic axis in BBRs anti-obesity pharmacology [182]

This heightens susceptibility to the toxic effects of iron overload, disrupting intestinal mucosal homeostasis and triggering local inflammation and cell death, ultimately precipitating the onset of gut-associated diseases ( 2.2 Iron overload, deficiency, and IBD pathogenesis In the intestinal microenvironment of IBD, iron overload or functional iron deficiency not only serves as a source of oxidative stress but also acts as a critical factor triggering ferroptosis in intestinal epithelial cells