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3), the median values (with minimum-maximum) of the urinary m 7 Gua levels at the initial visit to the tobacco cessation clinic, and at 2 and 8 weeks later were 27.32 (8.2141.30) g/mg creatinine, 16.17 (6.0558.94) g/mg creatinine, and 14.17 (6.0247.06) g/mg creatinine

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PMID 11988378

There is not a lot of concrete evidence that smoking causes sleep apnea, however, the link between the two is certain