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Since effective LDL-C reduction is the most important method to improve the prognosis in HoFH, intensive treatment should be carried out, involving all available interventions, i.e., high doses of potent statins, ezetimibe, PCSK9 inhibitors, and LDL apheresis [265, 284]

In the present study, we introduce NK-SADKA 2.0, a streamlined version designed to make more efficient use of limited primary cell samples