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GLP-1R is a B class G-protein-coupled receptor abundantly expressed in the pancreas and central nervous system, but also detected in lower levels in the gut, kidneys, lungs, liver, heart, muscle, peripheral nervous system, and other tissues ( GLP-1R mediated effects arise as a consequence of the immediate signaling cascade, which can impact insulin secretion and calcium flux in a rapid post translational modifications based manner ( Acute effects of GLP-1 in -cells Glucose enters the pancreatic -cells via the transporter, Glucose transporter 2 (GLUT2), moving down a concentration gradient from the capillaries

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Increased IMT during follow-up was diagnosed in 238 participants (15 %) and 328 (20 %) developed AS

Transition strategies: Gradual dose reduction (tapering) versus abrupt discontinuation both acceptable

Consult your healthcare provider to discuss treatment options