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The processes that govern such tumor heterogeneity and recurrence may be in part driven by the field cancerization effect, which refers to the development of a pre-malignant region that is predisposed to subsequent tumor formation through mutational accumulation 6,7

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The findings, just published in the journal Frontiers in Oncology, underscore the role of flavor and device type in the biological effects of vaping and could have regulatory implications as the Food and Drug Administration (FDA) moves to approve marketing of flavored vapes