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The pivotal trials enrolled hundreds of subjects and used CT-measured visceral adipose tissue (VAT) as the primary endpoint, a harder measure than BMI or waist circumference

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Unexpectedly, targeting ACLY (SB-204990), Acetyl-CoA Carboxylase 1 (ACC1, TOFA), FASN (TVB3166), FAO (etomoxir), LD biogenesis (Diacylglycerol Acyltransferase 1 and 2, DGAT1 and DGAT2, inhibitors) or lipid mobilization from LD (Adipose Triglyceride Lipase, ATGL, inhibitor, ATGListatin) showed no significant difference between 67NR and 4T1 cells (Fig

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